Universiteit Utrecht

Established in 1636, Utrecht University has evolved into a leading modern comprehensive research university with a growing international reputation. On the 2017 Shanghai Academic Ranking of World Universities, Utrecht University (UU) ranks first in the Netherlands, 22th in Europe and 47th in the world. UU has an annual turnover of over 810 million euro, 34% of which from external funding. UU has state-of-the art research facilities and excellent research training through graduate schools.

Regenerative Medicine Utrecht (RMU) brings together the largest number of researchers in the Netherlands to address global health care problems. They integrate fundamental science, emerging technologies, translational research and clinical care to perform high-quality research with the aim of developing novel regenerative treatments. The UU interdisciplinary group contributing to iPSpine is housed at the Regenerative Medicine Centre Utrecht which is next to The Hubrecht Institute – Netherlands Royal Academy of Sciences and in a walking distance from the Faculty of Veterinary Medicine.

The Faculty of Veterinary Medicine at Utrecht University is the premiere veterinary knowledge centre in the Netherlands. The Faculty of Veterinary Medicine is unique in that it offers knowledge and expertise of every level of animal health and welfare: from cell, to organism, to population. The faculty is ranked third in the QS World University Rankings (2018). Dedicated facilities/expertise of importance to iPSpine are the Gene Editing Facility (Prof. Niels Geijsen); Extracellular vesicle characterisation platform (Prof. Marc Wauben); and Regenerative orthopedics  headed by Prof. Tryfonidou. The UU group is renowned within the spine community for their unique preclinical platform enabling translation from bench to bedside with clinically relevant animal models. Herein, they have extensive experience in collaborating in multi-disciplinary consortia involving industry, academic and the public health sector.

Marianna Tryfonidou, Professor Regenerative Orthopedics, DVM, PhD, dipl ECVS joined the department of Clinical Sciences of Companion of the Faculty of Veterinary Medicine (1998), followed an annual Internship and finished thereafter her PhD (2002) Cum Laude. In 2007 she certified as a veterinary surgeon (European College of Veterinary Surgeons (ECVS)), in 2015 was appointed as Associate Professor and as off February 2018 appointed as Professor Regenerative Orthopedics. The focus of her research is on understanding the underlying pathophysiology, unravelling cellular communications and on developing treatment strategies for musculoskeletal diseases, including back pain and osteoarthritis. Challenges are addressed by combining their multidisciplinary clinical background, involving unique spontaneous diseased canine models, with cutting edge biomolecular techniques. Results of in vitro and in vivo studies are interpreted with a clinical directive; experiments are designed with the translation from bench to bed in mind.

Niels Geijssen, Professor Regenerative Medicine, received his PhD from UU in The Netherlands in 2000 studying cytokine signaling in the hematopoietic system. He completed his post-doctoral training in the lab of Dr. George Daley at MIT and the Whitehead Institute for Biomedical Research. He subsequently obtained a tenure- track faculty position at the Harvard Stem Cell Institute, where he developed novel methods for the genetic manipulation of human stem cells. In 2010 he became Professor of Regenerative Medicine at UU and relocated his research lab to the Hubrecht Institute where he and his team developed the iTOP protein transduction technology. Dr. Geijsen’s research focuses on understanding human genetic disorders using human pluripotent stem cells as the main model system. Prof Geijsen has a diverse team of 14 researchers, 6 post-doctoral fellows, 5 PhD students and 3 technicians and several master students. 48 papers have been published by Prof Geijsen (H-index 18, Web of Science).

Björn Meij, Professor of Small Animal Surgery, DVM, PhD, dipl ECVS (European College of Veterinary Surgeons). After graduating from the University of Ghent (Belgium) as a veterinarian, Björn Meij completed his internship and residency in Small Animal Surgery at the department of Companion Animals of the Faculty of Veterinary Medicine (UU). He has 25 years of clinical experience in specialized veterinary orthopedics and neurosurgery. Through successful collaborations with human colleagues in spine research in public-private research consortia (e.g., AOSpine and Dutch Arthritis Society), he has been able to translate the dog spine patient as an animal model  with spontaneous spine disease to the human side benefitting both humans and their best friend (dog). This platform complies with the 3Rs and is expected to help decrease the time to market of the ATMP therapeutics.

Frances Bach, DVM, PhD, post-doctoral scientist, obtained her propedeutic diploma in Biomedical Sciences (2005) and studied thereafter Veterinary Medicine (UU, the Netherlands). After obtaining her veterinary degree in 2012, Frances started her PhD on intervertebral disc regeneration under the supervision of Prof. Dr. Björn Meij (UU, the Netherlands) and Prof. Dr. Keita Ito (Eindhoven University of Technology and University Medical Center Utrecht, the Netherlands). Furthermore, she visited the laboratory of Prof. Danny Chan (The University of Hong Kong, China) and Prof. Dr. Daisuke Sakai (Tokai University School of Medicine, Japan), which resulted in three joint manuscripts exploring further fundamental aspects of disc biology. She recently obtained her PhD with Cum Laude and continues her research carrier focusing on NC- derived technologies within the (inter)national iPSpine network.

Deepani Poramba-Liyanage Having studied at the Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka, I was awarded the Utrecht Excellence Scholarship to study for my Masters in Cancer Genomics at Utrecht University. During my Masters, I focused on mass spectrometry (With Dr. Michiel Vermeulen at UMC, Utrecht) and in epigenetics using knockout mouse models for lymphoma (with Dr. Jan-Herman Dannenberg at the NKI, Amsterdam). My Ph.D. is in epigenetics and gene regulation in the lab of Dr. Fred van Leeuwen at the Netherlands Cancer Institute (NKI-AvL).  I now work as a postdoc in the lab of Marianna Tryfonidou as a part of the iPSpine team.